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Article

BIRC3 is a novel driver of therapeutic resistance in Glioblastoma

18 Feb 2016

Abstract excerpt

Genome-wide analysis of glioblastoma (GBM) reveals pervasive aberrations in apoptotic signaling pathways that collectively contribute to therapeutic resistance. Inhibitors of apoptosis proteins (IAP) exert critical control on the terminal segment of apoptosis leading to apoptosis evasion. In this study, we uncover a unique role for BIRC3, as an IAP that is critical in GBM in response to therapy. Using the TCGA...

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PMID: 26888114
DOI: 10.1038/srep21710

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