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Article

PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition

15 Jul 2022

Abstract excerpt

BACKGROUND: Resistance to temozolomide (TMZ) is a major obstacle to preventing glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) play a variety of roles in GBM, the lncRNAs that regulate TMZ resistance have not yet been clearly elucidated. This study aims to identify lncRNAs that may affect TMZ treatment sensitivity and to explore novel therapeutic strategies to overcome TMZ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35836243
DOI: 10.1186/s13046-022-02431-0

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