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Article

TRIP13 promotes the cell proliferation, migration and invasion of glioblastoma through the FBXW7/c-MYC axis

19 Nov 2019

Abstract excerpt

BACKGROUND: Thyroid hormone receptor interactor 13 (TRIP13) is an AAA + ATPase that plays an important role in the mitotic checkpoint. TRIP13 is highly expressed in various human tumours and promotes tumorigenesis. However, the biological effect of TRIP13 in GBM cells remains unclear. METHODS: We generated GBM cell models with overexpressed or silenced TRIP13 via lentivirus-mediated overexpression and RNAi...

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Share to Glioma Diagnosis and Treatment
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PMID: 31740732
DOI: 10.1038/s41416-019-0633-0

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