Article

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

2023-07-17

Abstract excerpt

Glioblastoma is the most prevalent and aggressive malignant tumor of the central nervous system. With a median overall survival of only one year, glioblastoma patients have a particularly poor prognosis, highlighting a clear need for novel therapeutic strategies to target this disease. Transcriptional cyclin-dependent kinases (tCDK), which phosphorylate key residues of RNA polymerase II (RNAPII) c-terminal domain...

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Literature Corpus work: 182f8186-8cd2-503c-a60b-4bd07e47707f
DOI: 10.1101/2023.07.14.548985

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