Article

RNA-Binding Protein IMP3 is a Novel Regulator of MEK1/ERK Signaling Pathway in the Progression of Colorectal Cancer through the Stabilization of MEKK1 mRNA

2021-05-27

Abstract excerpt

<h4>Background: </h4> MEK1/ERK signaling pathway plays an important role in most tumor progression, including colorectal cancer (CRC), however, MEK1-targeting therapy has little effective in treating CRC patients, indicating there may be a complex mechanism to activate MEK1/ERK signaling pathway except RAS activated mechanism. Methods To investigate the clinical significance of IMP3, we analyzed its expression le...

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Literature Corpus work: 3e5177d7-3a55-50fd-868a-c44716b22fe2
DOI: 10.21203/rs.3.rs-152463/v1

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