Article

How are<i>APOE4</i>, changes in body weight, and longevity related? Insights from a causal mediation analysis

2024-01-02

Abstract excerpt

The ε4 allele of the APOE gene ( APOE4) is known for its negative association with human longevity, however, the mechanism is unclear. APOE4 was also linked to changes in body weight, and the latter changes were associated with survival in some studies. Here we explore the role of aging changes in weight in the connection between APOE4 and longevity, using a Causal Mediation Analysis (CMA) approach to uncovering m...

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Literature Corpus work: d2fa3cd2-a662-542d-88c5-64270855a2d6
DOI: 10.1101/2023.12.27.23300485

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