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Article

Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study.

BMC medicine - 25 Feb 2026

Kong Lijie, Dou Chun, Ye Chaojie, Liu Dong, Chen Mingling, Zheng Jie, Xu Min, Xu Yu, Li Mian, Zhao Zhiyun, Lu Jieli, Chen Yuhong, Ning Guang, Wang Weiqing, Bi Yufang, Liu Ruixin, Wang Tiange

Abstract excerpt

BACKGROUND: Birthweight readily measurable marker of fetal growth that may influence health across the lifespan. We aimed to investigate the potential causal association between birthweight and healthy aging and to identify the mediating roles of subsequent socioeconomic, behavioral, functional, and disease-related factors to inform life-course strategies to promote healthy aging and reduce health inequities....

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PMID: 41735977
DOI: 10.1186/s12916-026-04737-8
PMCID: PMC13040693

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