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Article

The role of lipids in the effect of APOE2 on cognitive function: a causal mediation analysis.

European journal of epidemiology - 1 Dec 2025

Xiang Qingyan, Lok Judith J, Roth Nicole, Andersen Stacy L, Perls Thomas T, Song Zeyuan, Yashin Anatoli I, Mengel-From Jonas, Patti Gary J, Sebastiani Paola

Abstract excerpt

Extensive research has examined the direct effect of APOE alleles on cognitive decline. However, there is limited investigation into the effect of APOE that is explained or mediated through molecular pathways, such as lipids. In this study, we performed a causal mediation analysis to estimate both the direct effect of APOE2 and its indirect effect through 24 lipid species on cognitive function, measured from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41042284
DOI: 10.1007/s10654-025-01310-0
PMCID: PMC12756338

Genes

TG
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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