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Article

Mendelian randomization supports causality between overweight status and accelerated aging.

Aging cell - 1 Aug 2023

Chen Zong, Chen Zhiyou, Jin Xiaolei

Abstract excerpt

It is reported that overweight may lead to accelerated aging. However, there is still a lack of evidence on the causal effect of overweight and aging. We collected genetic variants associated with overweight, age proxy indicators (telomere length, frailty index and facial aging), etc., from genome-wide association studies datasets. Then we performed MR analyses to explore associations between overweight and age...

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PMID: 37277933
DOI: 10.1111/acel.13899
PMCID: PMC10410004

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