Article

Causal mediation analysis of the neuroprotection of<i>APOE2</i>through lipid pathways

2025-01-05

Abstract excerpt

<h4>Background</h4> Recent studies have revealed a strong association between the e2 allele of the Apolipoprotein E ( APOE2) gene and lipid metabolites. In addition, APOE2 carriers appear to be protected from cognitive decline and Alzheimer’s disease. This correlation supports the hypothesis that lipids may mediate the protective effect of APOE2 on cognitive function, thereby providing potential targets for therap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75fa11bf-7479-55ce-baf5-b03c81f06aee
DOI: 10.1101/2025.01.03.25319984

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Causal mediation analysis of the neuroprotection of<i>APOE2</i>through lipid pathwaysDOI 10.1101/2025.01.03.25319984Read

The role of lipids in the effect of APOE2 on cognitive function: a causal mediation analysis.Semantic proximity Read

Disentangling independent and mediated causal relationships between blood metabolites, cognitive factors, and Alzheimer’s DiseaseSemantic proximity Read

APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.Semantic proximity Read

How are<i>APOE4</i>, changes in body weight, and longevity related? Insights from a causal mediation analysisSemantic proximity Read

AD and non-AD mediators of the pathway between the APOE genotype and cognition.Semantic proximity Read

<i>APOE4</i> poses opposite effects of plasma LDL on white matter integrity in older adultsSemantic proximity Read

Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.Semantic proximity Read

Sex-Specific Protective Effects of APOE ε2 on Cognitive Performance.Semantic proximity Read

Walking to protect against cognitive decline: the role of APOE genotype and sex.Semantic proximity Read

Education, intelligence and Alzheimer’s disease: Evidence from a multivariable two-sample Mendelian randomization studySemantic proximity Read

Causal associations between socioeconomic status and Alzheimer’s disease: a Mendelian randomization and Mediation AnalysisSemantic proximity Read

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.Semantic proximity Read