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Article

Mediation of the APOE associations with Alzheimer's and coronary heart diseases through body mass index and lipids.

GeroScience - 1 Apr 2022

Loika Yury, Feng Fan, Loiko Elena, Kulminski Alexander M

Abstract excerpt

The APOE ε2/ε3/ε4 polymorphism is associated with multiple non-Mendelian traits, including high- (HDL-C) and low- (LDL-C) density lipoprotein cholesterol, triglycerides, body mass index (BMI), coronary heart disease (CHD), and Alzheimer's disease (AD). Lipids and BMI are risk factors for AD and CHD. Causal connections between the ε2 and ε4 alleles and these traits remain, however, poorly understood. We leverage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34554385
DOI: 10.1007/s11357-021-00458-3
PMCID: PMC9135946

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