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Trade-Off in the Effect of the <i>APOE</i> Gene on the Ages at Onset of Cardiocascular Disease and Cancer across Ages, Gender, and Human Generations

25 Oct 2012

Abstract excerpt

Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age and gender across generations in genetic trade-offs. The analyses show that the apolipoprotein E...

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PMID: 23094790
DOI: 10.1089/rej.2012.1362

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