Article

Predictable modulation of a spontaneous post-translational modification in living cells

2025-05-30

Abstract excerpt

Glycation is a non-enzymatic post-translational modification associated with aging and disease. Because it occurs spontaneously, it is extremely difficult to control the extent of glycation at distinct sites within target proteins, especially in cellular systems. Here we report a chemical approach, referred to as ‘dialAGE’, that enables the site-specific control of protein glycation. This unique tool requires the...

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Literature Corpus work: d2f3e3b3-73b0-5dd8-81cb-95ac5e5b0913
DOI: 10.1101/2025.05.28.656619

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