Article

A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine

2025-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Argpyrimidine (APY) is a methylglyoxal-derived advanced glycation end-product (AGE) that has been associated with multiple diseases. As APY forms without an enzyme, it remains exceptionally difficult to pinpoint where APY is likely to be found, both on individual proteins and in cells. In this study, we used a peptide model system and mass spectrometry analysis to investigate the chemical mechan...

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Literature Corpus work: 8e446001-ccd7-51a5-938e-4d067cd44237
DOI: 10.1101/2025.05.30.657038

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