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Article

Glycation potentiates neurodegeneration in models of Huntington's disease.

Scientific reports - 18 Nov 2016

Vicente Miranda Hugo, Gomes Marcos António, Branco-Santos Joana, Breda Carlo, Lázaro Diana F, Lopes Luísa Vaqueiro, Herrera Federico, Giorgini Flaviano, Outeiro Tiago Fleming

Abstract excerpt

Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. By modifying amino-groups, glycation interferes with folding of proteins, increasing their aggregation potential. Here, we studied the effect of pharmacological and genetic manipulation of glycation on huntingtin (HTT), the causative protein in...

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Identifiers

PMID: 27857176
DOI: 10.1038/srep36798
PMCID: PMC5114697

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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