Article
Metabolic precision labeling enables selective probing of O-linked <i>N</i> -acetylgalactosamine glycosylation
2020-04-25
Abstract excerpt
Protein glycosylation events that happen early in the secretory pathway are often dysregulated during tumorigenesis. These events can be probed, in principle, by monosaccharides with bioorthogonal tags that would ideally be specific for distinct glycan subtypes. However, metabolic interconversion into other monosaccharides drastically reduces such specificity in the living cell. Here, we use a structure-based desi...
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Identifiers and source
- Literature Corpus work
- ffb3de09-a474-5640-9a23-77f3c2530927
- DOI
- 10.1101/2020.04.23.057208