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Article

Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation.

Organic & biomolecular chemistry - 22 Nov 2016

Kekulandara Dilini N, Samarasinghe Kusal T G, Munkanatta Godage Dhanushka N P, Ahn Young-Hoon

Abstract excerpt

Protein glutathionylation is one of the major cysteine oxidative modifications in response to reactive oxygen species (ROS). We recently developed a clickable glutathione approach for detecting glutathionylation by using a glutathione synthetase mutant (GS M4) that synthesizes azido-glutathione (γGlu-Cys-azido-Ala) in situ in cells. In order to demonstrate the versatility of clickable glutathione and to increase...

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PMID: 27812596
DOI: 10.1039/c6ob02050j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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