Article

Seesaw Conformations of Npl4 in the Human p97 Complex and the Inhibitory Mechanism of a Disulfiram Derivative

2020-05-20

Abstract excerpt

<h4>ABSTRACT</h4> p97, also known as valosin-containing protein (VCP) or Cdc48, plays a central role in cellular protein homeostasis 1 . Human p97 mutations are associated with several neurodegenerative diseases 2,3 . Targeting p97 and its cofactors is a strategy for cancer drug development 4 . Despite significant structural insights into the fungal homolog Cdc48 5–7 , little is known about how human p97 inte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0b69b30-9a0c-50e7-b016-a14b44308f1e
DOI: 10.1101/2020.05.18.103085

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Seesaw Conformations of Npl4 in the Human p97 Complex and the Inhibitory Mechanism of a Disulfiram DerivativeDOI 10.1101/2020.05.18.103085Read

In silico prediction, Characterization, Docking studies and Molecular dynamics simulation of human p97 in complex with p37 cofactorSemantic proximity Read

Cryo-EM reveals disrupted human p97 allosteric activation by disease mutations and inhibitor bindingSemantic proximity Read

Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.Semantic proximity Read

Control of p97 function by cofactor binding.Semantic proximity Read

Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.Semantic proximity Read

Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding.Semantic proximity Read

Faf1 accelerates p97-mediated protein unfolding by promoting ubiquitin engagementSemantic proximity Read

<i>Streptococcus pyogenes</i> nuclease A interferes with host complement functionsSemantic proximity Read

p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral InfectionsSemantic proximity Read

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hcSemantic proximity Read

3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.Semantic proximity Read

Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy.Semantic proximity Read