Article
CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation.
Nature - 12 Jun 2014
Martin Emmanuel, Palmic Noé, Sanquer Sylvia, Lenoir Christelle, Hauck Fabian, Mongellaz Cédric, Fabrega Sylvie, Nitschké Patrick, Esposti Mauro Degli, Schwartzentruber Jeremy, Taylor Naomi, Majewski Jacek, Jabado Nada, Wynn Robert F, Picard Capucine, Fischer Alain, Arkwright Peter D, Latour Sylvain
Abstract excerpt
Lymphocyte functions triggered by antigen recognition and co-stimulation signals are associated with a rapid and intense cell division, and hence with metabolism adaptation. The nucleotide cytidine 5' triphosphate (CTP) is a precursor required for the metabolism of DNA, RNA and phospholipids. CTP originates from two sources: a salvage pathway and a de novo synthesis pathway that depends on two enzymes, the CTP...
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