Article

NQO1 phase condensation promotes stress granule assembly to facilitate pancreatic carcinogenesis

2025-09-29

Abstract excerpt

G3BP1 promotes pancreatic ductal adenocarcinoma (PDAC) tumorigenesis driven by oncogenic KRAS mutations through liquid-liquid phase separation (LLPS)-mediated assembly of stress granules (SGs). However, the regulatory mechanisms remain elusive. We identify the antioxidant enzyme NAD(P)H quinone dehydrogenase 1 (NQO1) as a novel SG regulator that enhances SG assembly in pancreatic cancer cells independently of rea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2b9ecd7-72d3-5461-af0e-f21e19660afe
DOI: 10.1101/2025.09.25.678687

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NQO1 phase condensation promotes stress granule assembly to facilitate pancreatic carcinogenesisDOI 10.1101/2025.09.25.678687Read

Is there a role of phase partitioning in coordinating DNA damage response?Semantic proximity Read

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level RegulationSemantic proximity Read

Aberrant phase separation and cancer.Semantic proximity Read

Protein phase separation and its role in tumorigenesis.Semantic proximity Read

Liquid‒liquid phase separation: roles and implications in future cancer treatment.Semantic proximity Read

C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1Semantic proximity Read

Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment.Semantic proximity Read

Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosisSemantic proximity Read

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteinsSemantic proximity Read

PTK6 drives HNRNPH1 phase separation to activate autophagy and suppress apoptosis in colorectal cancerSemantic proximity Read

Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferaseSemantic proximity Read

A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cellsSemantic proximity Read