Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTK6 drives HNRNPH1 phase separation to activate autophagy and suppress apoptosis in colorectal cancer

19 Mar 2025

Abstract excerpt

Macroautophagy/autophagy is the principal mechanism that mediates the delivery of various cellular cargoes to lysosomes for degradation and recycling, and has been reported to play a crucial role in colorectal cancer (CRC) pathogenesis and progression. Targeting autophagy may be a promising therapeutic strategy for CRC. However, the specific functions and potential mechanisms of autophagy in CRC remain unclear....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40103198
DOI: 10.1080/15548627.2025.2481001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTK6 drives HNRNPH1 phase separation to activate autophagy and suppress apoptosis in colorectal cancerPMID 40103198Read ↗

Systematic Analysis of Molecular Characterization and Clinical Relevance of Liquid–Liquid Phase Separation Regulators in Digestive System NeoplasmsSemantic proximity Read ↗

WDR3 undergoes phase separation to mediate the therapeutic mechanism of Nilotinib against osteosarcomaSemantic proximity Read ↗

NKD1 targeting PCM1 regulates the therapeutic effects of HHT on colorectal cancer cellsSemantic proximity Read ↗

NUP43 promotes PD-L1/nPD-L1/PD-L1 feedback loop via TM4SF1/JAK/STAT3 pathway in colorectal cancer progression and metastatsisSemantic proximity Read ↗

LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axisSemantic proximity Read ↗

Aberrant phase separation and cancer.Semantic proximity Read ↗

Liquid‒liquid phase separation: roles and implications in future cancer treatment.Semantic proximity Read ↗

Liquid-liquid phase separation-related signature predicts prognosis and therapeutic response in esophageal adenocarcinoma.Semantic proximity Read ↗

LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesisSemantic proximity Read ↗

Protein phase separation and its role in tumorigenesis.Semantic proximity Read ↗

NKD1 targeting PCM1 regulates the therapeutic sensitivity of HHT on colorectal cancer cellsSemantic proximity Read ↗

The role of liprin-α1 phosphorylation in its liquid-liquid phase separation: regulation by PPP2R5D/PP2A holoenzymeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.