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Article

Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13.

Nature communications - 13 Jan 2025

Cheng Shang-Jung, Gafaar Temitope, Kuttiyatveetil Jijin R A, Sverzhinsky Aleksandr, Chen Carla, Xu Minghui, Lilley Allison, Pascal John M, Leung Anthony K L

Abstract excerpt

Non-covalent interactions of poly(ADP-ribose) (PAR) facilitate condensate formation, yet the impact of these interactions on condensate properties remains unclear. Here, we demonstrate that PAR-mediated interactions through PARP13, specifically the PARP13.2 isoform, are essential for modulating the dynamics of stress granules-a class of cytoplasmic condensates that form upon stress, including types frequently...

Read the complete abstract on PubMed

Topics

Humans
Poly Adenosine Diphosphate Ribose
Stress Granules
Poly(ADP-ribose) Polymerases
Protein Binding

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

HeLa Cells

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Identifiers

PMID: 39805863
DOI: 10.1038/s41467-024-55666-0
PMCID: PMC11731017

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