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Article

Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment.

Cancer research - 15 May 2023

Sekhar Konjeti R, Freeman Michael L

Abstract excerpt

Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid-liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36877156
DOI: 10.1158/0008-5472.CAN-22-3631
PMCID: PMC10183826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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