Article

Spatial Transcriptomics of Schizophrenia Insular Cortex Reveals Blood-Brain Barrier Hyperglycolysis and Increased Parenchymal Mitochondrial Respiration

2025-03-13

Abstract excerpt

<h4>Introduction</h4> The blood-brain barrier (BBB) acts as the metabolic and immunological gatekeeper of the brain. Since alterations in neurometabolism and neuroimmunity are found in schizophrenia-spectrum disorders (SSD) which are hypothesised to be important disease mechanisms, we aimed to investigate whether changes in BBB function could underly these findings using a novel spatially resolved transcriptomics...

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Literature Corpus work: d2a7c5bd-6caf-5f41-baa2-6d42de1c4a58
DOI: 10.1101/2025.03.12.642911

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