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Article

A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function.

Molecular brain - 5 Dec 2025

Zhu Xiaoyang, Wang Shengjie, Zhang Shuaiqi, Liu Zhiyuan, Wang Na, Wang Shu, Yang Nixia

Abstract excerpt

The glymphatic system plays a key role in brain waste clearance, but its genetic regulation remains poorly understood. Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) index is a non-invasive imaging biomarker to asses glymphatic system activity. We integrated mean DTI-ALPS genome-wide association study (GWAS) data from 31,021 individuals of European ancestry with GTEx v8 multi-tissue eQTL...

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Source

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Identifiers

PMID: 41351017
DOI: 10.1186/s13041-025-01258-y
PMCID: PMC12681178

Genes

GCAT
MAPRE3
TRIOBP
EMILIN1
CGREF1
KHK
AGBL5
CENPA
DNAJC5G
OTOF
PLCL1
RBM43
RFTN2
SERPIND1
SNAP29
UCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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