Article
A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function.
Molecular brain - 5 Dec 2025
Zhu Xiaoyang, Wang Shengjie, Zhang Shuaiqi, Liu Zhiyuan, Wang Na, Wang Shu, Yang Nixia
Abstract excerpt
The glymphatic system plays a key role in brain waste clearance, but its genetic regulation remains poorly understood. Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) index is a non-invasive imaging biomarker to asses glymphatic system activity. We integrated mean DTI-ALPS genome-wide association study (GWAS) data from 31,021 individuals of European ancestry with GTEx v8 multi-tissue eQTL...
Topics
- Humans
- Genome-Wide Association Study
- Transcriptome
- Glymphatic System
- Brain
- Organ Specificity
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Mendelian Randomization Analysis
- Diffusion Tensor Imaging