Article

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

2026-02-17

Abstract excerpt

<h4>Summary</h4> The dorsolateral prefrontal cortex (dlPFC) is central to cognitive dysfunction in schizophrenia (SCZ), yet how molecular changes are organized across cortex remains unclear. Here, we applied complementary spatial transcriptomic approaches spanning laminar domains, microenvironments, and cell types in postmortem human dlPFC. At the laminar level, SCZ-associated transcriptional changes were stronge...

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Literature Corpus work: 8870cba7-c984-5f81-ada4-0e70ed272366
DOI: 10.64898/2026.02.16.706214

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