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Article

Shared Molecular Landscape of Human Brain Structure and Systemic Metabolism

2025-01-14

Abstract excerpt

The human brain is metabolically demanding, yet the causal interplay between systemic metabolism and brain morphology remains largely unknown. Applying systematic phenome- and genome-wide analyses of 24,940 UK Biobank participants, integrating 249 NMR-derived plasma metabolic markers with MRI-derived brain morphology, we revealed extensive phenotypic associations, with 236 of 249 metabolites linked to at least one...

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Identifiers and source

Literature Corpus work
04ee025e-3780-5502-843e-cb730e6479d1
DOI
10.1101/2025.01.12.632645
Open publication

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Shared Molecular Landscape of Human Brain Structure and Systemic MetabolismDOI 10.1101/2025.01.12.632645
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