Article

A multilayer genomic framework linking insomnia to glymphatic system function through pleiotropic mechanisms at 17q21.31

2026-02-25

Abstract excerpt

<title>Abstract</title> <p> Sleep plays a critical role in brain waste clearance, yet whether insomnia shares a genetic basis with the glymphatic system (GS)—a glia-dependent perivascular pathway involved in metabolite removal—remains unclear. Here, we integrated large-scale genome-wide association studies (GWAS) of insomnia with diffusion tensor imaging along the perivascular space (DTI–ALPS), an imaging-derive...

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Identifiers and source

Literature Corpus work: b85ade28-75ac-5268-84fe-701777611332
DOI: 10.21203/rs.3.rs-8585990/v1

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