Article

Yeast NDI1 expression prevents the unfolded protein response and reconfigures metabolism to restore neuronal function in mitochondrial complex I deficiency

2022-09-23

Abstract excerpt

Mutations in mitochondrial complex I cause mitochondrial complex I deficiency, a group of severe neurological diseases that can result in death in infancy. The mechanisms underlying complex I deficiency pathogenesis remain poorly understood, and as a result there are currently no available treatments. To better understand the causes of neuronal dysfunction in complex I deficiency, we modelled complex I deficiency...

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Literature Corpus work: 8bded80f-a006-54d0-899d-6b446fdd81fa
DOI: 10.1101/2022.09.22.509020

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