Article

Studies on assembly and genetic variation in mitochondrial respiratory complex I

2019-01-01

Abstract excerpt

Complex I (NADH:ubiquinone oxidoreductase) couples electron transfer to proton translocation across the inner mitochondrial membrane, to drive the synthesis of ATP. Its distinctive L-shaped structure comprises 45 subunits, encoded by both the mitochondrial and nuclear genomes, which are assembled by a complicated modular pathway. Complex I genetic defects are the most common cause of mitochondrial disorders and of...

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Literature Corpus work: b7d3de7b-0315-5412-ac45-02f5c4c779d5
DOI: 10.17863/cam.36634

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