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<i> ndufs2 <sup>-/-</sup> </i> zebrafish have impaired survival, neuromuscular activity, morphology, and one-carbon metabolism treatable with folic acid

2025-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial complex I (CI) deficiency represents a common biochemical pathophysiology underlying Leigh syndrome spectrum (LSS), manifesting with progressive multi-system dysfunction, lactic acidemia, and early mortality. To facilitate mechanistic studies and rigorous screening of therapeutic candidates for CI deficient LSS, we used CRISPR/Cas9 to generate an ndufs2 -/- 16 bp deletion zebrafi...

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Literature Corpus work
7b01acc8-bf30-571d-bd1e-f8a83debc591
DOI
10.1101/2025.07.16.664929
Open publication

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