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Article

Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila

1 Apr 2018

Abstract excerpt

Legionella pneumophila translocates the largest known arsenal of over 330 pathogenic factors, called "effectors," into host cells during infection, enabling L. pneumophila to establish a replicative niche inside diverse amebas and human macrophages. Here, we reveal that the L. pneumophila effectors MavC (Lpg2147) and MvcA (Lpg2148) are structural homologs of cycle inhibiting factor (Cif) effectors and that the...

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PMID: 29642013
DOI: 10.1016/j.celrep.2018.03.060

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