Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>Mycobacterium tuberculosis</i> PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?

1 Jan 2014

Abstract excerpt

Necrotic cell death during TB infection is an important prerequisite for bacterial dissemination and virulence. The underlying mechanisms and the bacterial factors involved therein are not well understood. The Mycobacterium tuberculosis (M. tuberculosis) co-operonic PE25/PPE41 protein complex, similar to ESAT-6/CFP-10, belonging to the PE/PPE and ESAT-6 families of genes has co-expanded and co-evolved in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Pneumonia and Respiratory Infections
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25379378
DOI: 10.1016/j.fob.2014.09.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>Mycobacterium tuberculosis</i> PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?PMID 25379378Read ↗

Immunoregulatory functions and expression patterns of PE/PPE family members: Roles in pathogenicity and impact on anti‐tuberculosis vaccine and drug designSemantic proximity Read ↗

Role of the PE/PPE Family in Host–Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool DesignSemantic proximity Read ↗

The <i>PPE25 (Rv1787) - PE18 (Rv1788) - PPE26 (Rv1789)</i> gene cluster encodes an interacting protein pair and is involved in immune evasion by <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

The PE-PPE Family of Mycobacterium tuberculosis: Proteins in DisguiseSemantic proximity Read ↗

Master control of protein secretion by <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read ↗

Delineating the functional role of the <i>PPE50 (Rv3135) - PPE51 (Rv3136)</i> gene cluster in the pathophysiology of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide productionSemantic proximity Read ↗

Loss of the <i>PPE71-esxX-esxY-PPE38</i> locus drives adaptive transcriptional responses and hypervirulence of <i>Mycobacterium tuberculosis</i> Lineage 2Semantic proximity Read ↗

Disruption of the ESX‐5 system of <i>Mycobacterium tuberculosis</i> causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuationSemantic proximity Read ↗

Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host DefenseSemantic proximity Read ↗

PE11, a PE/PPE family protein of Mycobacterium tuberculosis is involved in cell wall remodeling and virulenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.