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<i>Legionella</i> translocates an E3 ubiquitin ligase that has multiple U‐boxes with distinct functions

13 Feb 2008

Abstract excerpt

Legionella pneumophila has a Dot/Icm type IV secretion system used to translocate a number of 'effector proteins' which subvert host cell functions. In this study, we identified 19 novel Dot/Icm substrate proteins using a systematic screening technique. A blast analysis revealed that one of the substrates, which we named LubX (LegionellaU-box protein), contains two domains that have a remarkable similarity to the...

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PMID: 18284575
DOI: 10.1111/j.1365-2958.2008.06124.x

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