The exploitation of host autophagy and ubiquitin machinery by <i>Mycobacterium tuberculosis</i> in shaping immune responses and host defense during infection

Abstract excerpt

Intracellular pathogens have evolved various efficient molecular armaments to subvert innate defenses. Cellular ubiquitination, a normal physiological process to maintain homeostasis, is emerging one such exploited mechanism. Ubiquitin (Ub), a small protein modifier, is conjugated to diverse protein substrates to regulate many functions. Structurally diverse linkages of poly-Ub to target proteins allow enormous...

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