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The <i>Shigella</i> E3 ubiquitin ligase IpaH7.8 reprograms host kinase signaling to suppress NOX2-dependent oxidative burst responses in human monocytes

2026-05-01

Abstract excerpt

Bacterial effector proteins manipulate host signalling cascades, including immune responses, to facilitate infection. While most effectors of Gram-negative bacteria rely on a secretion system for intracellular delivery, some possess intrinsic cell-penetrating capabilities. Here, we characterize the Shigella flexneri LPX effector IpaH7.8, which combines autonomous cell entry with enzymatic modulation of immunomodu...

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Literature Corpus work
6aef7d87-1e57-5d8a-8a43-947deee56317
DOI
10.64898/2026.04.28.721327
Open publication

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The <i>Shigella</i> E3 ubiquitin ligase IpaH7.8 reprograms host kinase signaling to suppress NOX2-dependent oxidative burst responses in human monocytesDOI 10.64898/2026.04.28.721327
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