Article

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder

2021-10-12

Abstract excerpt

Genetic studies implicate disruption to the DLG2 gene in copy number variants as increasing risk for schizophrenia, autism spectrum disorders and intellectual disability. To investigate psychiatric endophenotypes associated with DLG2 haploinsufficiency (and concomitant PSD-93 protein reduction) a novel clinically relevant Dlg2 +/- rat was assessed for abnormalities in anxiety, sensorimotor gating, hedonic react...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d28aed4e-3c23-5426-a676-3ac8530e29be
DOI: 10.1101/2021.10.11.463943

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorderDOI 10.1101/2021.10.11.463943Read

Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene <i>DLG2</i>Semantic proximity Read

Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticitySemantic proximity Read

Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour.Semantic proximity Read

Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene.Semantic proximity Read

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model.Semantic proximity Read

Cell-type selective deletion of RSK2 reveals insights into altered signaling in Coffin-Lowry SyndromeSemantic proximity Read

Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects.Semantic proximity Read

Further confirmation of the association between anxiety and CTNND2: replication in humans.Semantic proximity Read

Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication.Semantic proximity Read

Heritable differences in the dopaminergic regulation of behavior in rats: relationship to D2-like receptor G-protein function.Semantic proximity Read

Changes in Dpysl2 expression are associated with prenatally stressed rat offspring and susceptibility to schizophrenia in humans.Semantic proximity Read