Article

Cell-type selective deletion of RSK2 reveals insights into altered signaling in Coffin-Lowry Syndrome

2017-06-26

Abstract excerpt

<h4>ABSTRACT</h4> Coffin-Lowry syndrome (CLS) is an X-linked syndromic form of mental retardation characterized by various skeletal dysmorphisms, moderate to severe mental retardation, and in some cases, psychosis. CLS is caused by loss-of-function mutations of the p90 ribosomal S6 kinase 2 (RPS6KA3) gene encoding a growth factor-regulated serine/threonine kinase, ribosomal S6 kinase 2 (RSK2). We previously ident...

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Literature Corpus work: a5b35105-da37-5914-9aa4-9bdada58572b
DOI: 10.1101/156257

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