Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour.

doi:10.1016/j.neuropharm.2016.03.020

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour.

Neuropharmacology - 15 Mar 2017

Wood Christian M, Nicolas Celine S, Choi Sun-Lim, Roman Erika, Nylander Ingrid, Fernandez-Teruel Alberto, Kiianmaa Kalervo, Bienkowski Przemyslaw, de Jong Trynke R, Colombo Giancarlo, Chastagnier Denis, Wafford Keith A, Collingridge Graham L, Wildt Sheryl J, Conway-Campbell Becky L, Robinson Emma S J, Lodge David

Abstract excerpt

Modulation of metabotropic glutamate 2 (mGlu2) receptor function has huge potential for treating psychiatric and neurological diseases. Development of drugs acting on mGlu2 receptors depends on the development and use of translatable animal models of disease. We report here a stop codon mutation at cysteine 407 in Grm2 (cys407*) that is common in some Wistar rats. Therefore, researchers in this field need to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystine

Share to Emotions

Share to Hippocampus

Share to Organ Culture Techniques

Share to Rats, Wistar

Share to Receptors, Metabotropic Glutamate

Share to Risk-Taking

Source

Open in PubMed

Identifiers

PMID: 26987983
DOI: 10.1016/j.neuropharm.2016.03.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour.PMID 26987983Read ↗

Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking?Semantic proximity Read ↗

Systematic generation of in vivo G protein-coupled receptor mutants in the rat.Semantic proximity Read ↗

Pharmacogenetic Effects of Naltrexone in Individuals of East Asian Descent: Human Laboratory Findings from a Randomized Trial.Semantic proximity Read ↗

Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice.Semantic proximity Read ↗

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorderSemantic proximity Read ↗

Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene.Semantic proximity Read ↗

A common molecular mechanism for cognitive deficits and craving in alcoholismSemantic proximity Read ↗

Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.Semantic proximity Read ↗

The Wistar-Kyoto rat as a model relevant to inattentive ADHD: substrain variability and affective comorbidity.Semantic proximity Read ↗

Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking.Semantic proximity Read ↗

Further characterization of the GlyT-1 inhibitor Org25935: anti-alcohol, neurobehavioral, and gene expression effects.Semantic proximity Read ↗

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.