Article
Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene.
Disease models & mechanisms - 1 Apr 2017
Vengeliene Valentina, Bespalov Anton, Roßmanith Martin, Horschitz Sandra, Berger Stefan, Relo Ana L, Noori Hamid R, Schneider Peggy, Enkel Thomas, Bartsch Dusan, Schneider Miriam, Behl Berthold, Hansson Anita C, Schloss Patrick, Spanagel Rainer
Abstract excerpt
The research domain criteria (RDoC) matrix has been developed to reorient psychiatric research towards measurable behavioral dimensions and underlying mechanisms. Here, we used a new genetic rat model with a loss-of-function point mutation in the dopamine transporter (DAT) gene (Slc6a3_N157K) to systematically study the RDoC matrix. First, we examined the impact of the Slc6a3_N157K mutation on monoaminergic...
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