Article
The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model.
Disease models & mechanisms - 1 Oct 2016
Homberg Judith R, Olivier Jocelien D A, VandenBroeke Marie, Youn Jiun, Ellenbroek Arabella K, Karel Peter, Shan Ling, van Boxtel Ruben, Ooms Sharon, Balemans Monique, Langedijk Jacqueline, Muller Mareike, Vriend Gert, Cools Alexander R, Cuppen Edwin, Ellenbroek Bart A
Abstract excerpt
Social cognition is an endophenotype that is impaired in schizophrenia and several other (comorbid) psychiatric disorders. One of the modulators of social cognition is dopamine, but its role is not clear. The effects of dopamine are mediated through dopamine receptors, including the dopamine D1 receptor (Drd1). Because current Drd1 receptor agonists are not Drd1 selective, pharmacological tools are not sufficient...
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