Article

Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity

2021-08-04

Abstract excerpt

<h4>Background: </h4> Genetic variations indicating loss of function in the DLG2 gene have been associated with markedly increased risk for schizophrenia, autism spectrum disorder, and intellectual disability. DLG2 encodes the postsynaptic scaffolding protein DLG2 (PSD93) that interacts with NMDA receptors, potassium channels, and cytoskeletal regulators but the net impact of these interactions on synaptic plast...

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Literature Corpus work: 218a4aaa-4997-58d5-8c85-4c0e2b04cf2f
DOI: 10.1101/2021.08.02.454736

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