Article
Heritable differences in the dopaminergic regulation of behavior in rats: relationship to D2-like receptor G-protein function.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2006
Swerdlow Neal R, Krupin Alison S, Bongiovanni Michele J, Shoemaker Jody M, Goins Jana C, Hammer Ronald P
Abstract excerpt
We reported heritable differences between Sprague-Dawley (SD) and Long Evans (LE) rats in their sensitivity to the disruption of prepulse inhibition of startle (PPI) by dopamine (DA) agonists, and in their basal levels and turnover of forebrain DA. In an effort to better understand these differences, we assessed strain patterns in the efficacy of D2-like receptor-G-protein coupling using [35S]GTPgammaS binding in...
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