Article

Optogenetic Engineering of BAX to Control Mitochondrial Permeabilization and Attenuate Apoptosis in Cells

2025-04-22

Abstract excerpt

<title>Abstract</title> <p>Although considerable research has focused on enhancing the apoptotic function of BAX for several decades, inhibition of its functionality remains relatively underexplored, despite intensive BAX activation occurring in various neurodegenerative diseases. Here we present a protein engineering approach to modulate BAX integration into the mitochondrial outer membrane, establishing a tunab...

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Literature Corpus work: d28aad52-183a-53e5-b588-bd416aac9139
DOI: 10.21203/rs.3.rs-6222702/v1

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