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Article

Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.

The Journal of biological chemistry - 21 Nov 2014

Gahl Robert F, He Yi, Yu Shiqin, Tjandra Nico

Abstract excerpt

The B-cell lymphoma 2 (Bcl-2) family of proteins regulates the activation of apoptosis through the mitochondria pathway. Pro- and anti-apoptotic members of this family keep each other in check until the correct time to commit to apoptosis. The point of no return for this commitment is the permeabilization of the outer mitochondrial membrane. Translocation of the pro-apoptotic member, Bax, from the cytosol to the...

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Identifiers

PMID: 25315775
DOI: 10.1074/jbc.M114.593897
PMCID: PMC4239635

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Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.PMID 25315775Read ↗

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The Bax carboxy-terminal hydrophobic helix does not determine organelle-specific targeting but is essential for maintaining Bax in an inactive state and for stable mitochondrial membrane insertion.Semantic proximity Read ↗

BAX activation is initiated at a novel interaction site.Semantic proximity Read ↗

Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif.Semantic proximity Read ↗

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