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Article

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis.

The EMBO journal - 15 Jun 2005

Annis Matthew G, Soucie Erinn L, Dlugosz Paulina J, Cruz-Aguado Jorge A, Penn Linda Z, Leber Brian, Andrews David W

Abstract excerpt

Bax promotes cell death by permeabilizing mitochondrial outer membranes by an unresolved mechanism. However, in cells lacking the gene c-myc, membrane permeabilization by Bax is blocked by changes in the mitochondria that prevent Bax oligomerization. Drug-treated c-myc null cells and cells expressing Myc were used to map the topology of Bax in membranes prior to and after mitochondrial permeabilization. Chemical...

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Share to bcl-2-Associated X Protein
Share to BH3 Interacting Domain Death Agonist Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochromes c

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Source

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Identifiers

PMID: 15920484
DOI: 10.1038/sj.emboj.7600675
PMCID: PMC1150878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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