Article

Precisely control mitochondria with light to manipulate cell fate decision

2018-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial dysfunction has been implicated in many pathological conditions and diseases. The normal functioning of mitochondria relies on maintaining the inner mitochondrial membrane (IMM) potential ( a.k.a. ΔΨ m ) that is essential for ATP synthesis, Ca 2+ homeostasis, redox balance and regulation of other key signaling pathways such as mitophagy and apoptosis. However, the detailed mecha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: faeb3aa4-ad56-5528-a390-16b9d42ccd84
DOI: 10.1101/469668

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Precisely control mitochondria with light to manipulate cell fate decisionDOI 10.1101/469668Read

Optogenetic Regulation of Mitochondrial Function to Modulate Cell DeathSemantic proximity Read

Targeting high-density aromatic peptides to cardiolipin optimizes the mitochondrial membrane potentialSemantic proximity Read

A Reversible Mitochondrial ROS Probe for Monitoring Mitophagy Dynamics: Development and Application of MitoFlareSemantic proximity Read

Optogenetic Engineering of BAX to Control Mitochondrial Permeabilization and Attenuate Apoptosis in CellsSemantic proximity Read

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca <sup>2+</sup> uptake and oxidative metabolismSemantic proximity Read

Optogenetic delivery of trophic signals in a genetic model of Parkinson’s diseaseSemantic proximity Read

Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor.Semantic proximity Read

Channelrhodopsin Ion Selectivity Determines Mechanisms and Efficacy of Optogenetic Defibrillation in Human Atria and VentriclesSemantic proximity Read

Controlling Engineered P2X Receptors with Light.Semantic proximity Read

Optogenetic Control of Mammalian Ion Channels with Chemical Photoswitches.Semantic proximity Read

Use of genetically encoded, light-gated ion translocators to control tumorigenesis.Semantic proximity Read

Efficient and sustained optogenetic control of sensory and cardiac systemsSemantic proximity Read