Article
Conformation of the Bax C-terminus regulates subcellular location and cell death.
The EMBO journal - 4 May 1999
Nechushtan A, Smith C L, Hsu Y T, Youle R J
Abstract excerpt
Bax, a pro-apoptotic member of the Bcl-2 family, translocates from the cytosol to the mitochondria during programmed cell death. We report here that both gain-of-function and loss-of-function mutations can be achieved by altering a single amino acid in the Bax hydrophobic C-terminus. The properly mutated C-terminus of Bax can target a non-relevant protein to the mitochondria, showing that specific conformations...
Topics
- Amino Acid Sequence
- Apoptosis
- Biological Transport
- Cell Compartmentation
- Cytoplasm
- Humans
- Mitochondria
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Sequence Deletion
- bcl-2-Associated X Protein
- bcl-X Protein