Article

An optimized high-yield protocol for expression and purification of monomeric full-length BAX protein

2023-10-19

Abstract excerpt

Diverse developmental signals and pro-death stresses converge on regulation of the mitochondrial pathway of apoptosis. BAX, a pro-apoptotic BCL-2 effector, directly forms proteolipid pores in the outer mitochondrial member to activate the mitochondrial pathway of apoptosis. BAX is a viable pharmacological target for various human diseases, and increasing efforts have been made to study the molecular regulation of...

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Literature Corpus work: 7ee83be1-81ae-5edb-8f4c-3083334477d0
DOI: 10.1101/2023.10.16.562589

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