Article

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

2023-10-27

Abstract excerpt

<h4>Background</h4> Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter-and intra-tumoral heterogeneity of antigen landscape hampers therapeutic development. Therefore, it is critical to consider alternative sources to expand the repertoire of targetable (neo-)antigens and improve therapeutic outcomes. Accumulating evidence suggests that tumor-specifi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07c2ceef-95cc-589b-9f1c-7c2561e84d3a
DOI: 10.1101/2023.10.26.564156

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in gliomaDOI 10.1101/2023.10.26.564156Read

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in gliomaSemantic proximity Read

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigensSemantic proximity Read

Neoantigens in cancer immunotherapy: focusing on alternative splicingSemantic proximity Read

Identification and prioritisation of tumour antigen candidates from 79 glioblastoma transcriptomes.Semantic proximity Read

Decoding Neoantigen-encoding Tumor-Specific Transcripts Unveils a Shared Target Reservoir for Immunotherapy in Hepatocellular CarcinomaSemantic proximity Read

Targeting alternative splicing in cancer immunotherapySemantic proximity Read

Deciphering the role of alternative splicing in neoplastic diseases for immune-oncological therapiesSemantic proximity Read

Tumour-wide RNA splicing aberrations generate actionable public neoantigensSemantic proximity Read

Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapySemantic proximity Read

The cancer exome generated by alternative mRNA splicing dilutes predicted HLA class I epitope density.Semantic proximity Read

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigensSemantic proximity Read

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltrationSemantic proximity Read